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What causes Alzheimer's disease?

Jul 19, 2025 Source: Cainiu Health
Dr. Wang Lei
Introduction
Under normal circumstances, Alzheimer's disease may be caused by factors such as aging, genetic predisposition, β-amyloid protein deposition, abnormal phosphorylation of tau protein, and cerebrovascular disease. If experiencing any discomfort, it is recommended to seek medical attention promptly. In daily life, it is important to maintain a positive mindset and avoid prolonged mental stress; engage in social interactions and participate in social activities.

Under normal circumstances, Alzheimer's disease may be caused by aging, genetic factors, β-amyloid protein deposition, abnormal phosphorylation of tau protein, cerebrovascular disease, and other factors. If experiencing any discomfort, prompt medical consultation is recommended. Detailed explanations are as follows:

1. Aging

With advancing age, brain nerve cells gradually degenerate and brain function declines, increasing the risk of Alzheimer's disease. Maintaining regular sleep patterns, engaging in moderate exercise such as walking or tai chi, and promoting cerebral blood circulation are recommended. Additionally, participating in mentally stimulating activities such as reading or playing chess can help exercise brain function.

2. Genetic Factors

Some individuals are more susceptible to neurodegenerative changes in the brain due to carrying specific disease-related genes, which may lead to Alzheimer's disease. Those with a family history should pay attention to brain health earlier and undergo regular cognitive function assessments. Maintaining a balanced diet and consuming more foods rich in unsaturated fatty acids is also important in daily life.

3. β-Amyloid Protein Deposition

Abnormal deposition of β-amyloid protein in the brain forms plaques that damage nerve cells, leading to cognitive decline. Patients should take medications such as donepezil hydrochloride tablets, rivastigmine tartrate capsules, and memantine hydrochloride tablets under medical guidance to improve cognitive function.

4. Abnormal Phosphorylation of Tau Protein

Following abnormal phosphorylation, tau proteins form tangles that affect the normal function and signal transmission of nerve cells, worsening cognitive impairment. Under medical supervision, patients can take medications such as oxiracetam capsules, piracetam tablets, and sodium citicoline tablets to protect nerve cells and improve brain metabolism.

5. Cerebrovascular Disease

Cerebrovascular disease can impair blood supply to the brain, causing ischemia and hypoxia of nerve cells, which may trigger or exacerbate Alzheimer's disease and could be accompanied by difficulty in limb movement. Patients should use medications such as aspirin enteric-coated tablets, atorvastatin calcium tablets, and ginkgo biloba extract tablets under medical guidance to improve cerebral blood circulation.

In daily life, maintaining a positive mindset and avoiding prolonged mental stress is important. Engaging in social interaction and participating in social activities, as well as eating a balanced diet with reduced intake of high-fat and high-sugar foods, are also recommended.

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