Is it better to have high or low high-density lipoprotein cholesterol?
Aug 18, 2025
Source: Cainiu Health
Dr. Tian Hongbo
Introduction
Too low levels may increase the risk of cardiovascular diseases, as they can transport excess cholesterol from blood vessels to the liver for metabolism. When levels are insufficient, cholesterol tends to deposit on the vessel walls, which may lead to atherosclerosis and other issues, adversely affecting vascular health. Conversely, excessively high levels are also not beneficial and may indicate abnormal metabolism or be associated with certain diseases, thereby affecting the balance of lipid metabolism.
Generally, it is best for high-density lipoprotein (HDL) cholesterol to remain within the normal range—not too low and not too high. If abnormalities are detected, prompt medical attention is recommended. Detailed analysis is as follows:
Levels that are too low may increase the risk of cardiovascular disease, as HDL cholesterol helps transport excess cholesterol from blood vessels to the liver for metabolism. When HDL levels are insufficient, cholesterol can deposit on blood vessel walls, potentially leading to issues such as atherosclerosis, which is detrimental to vascular health.
Elevated levels are also not necessarily beneficial. They may indicate abnormal metabolism or be associated with certain diseases, affecting the balance of lipid metabolism. High HDL levels may also interfere with the interpretation of other lipid indicators, making it difficult to fully assess overall health status.
Determining whether HDL cholesterol levels are appropriate requires consideration of overall lipid levels and general health. Regular testing is recommended, and if results are abnormal, further investigations should be conducted to identify the underlying cause. Lifestyle adjustments or interventions should follow professional guidance.
