Which medications may trigger Parkinson's syndrome in children?

Generally, childhood Parkinsonism is often triggered by genetic factors, brain injuries, or adverse drug reactions. Some medications may affect dopamine metabolism or receptor function in children's brains and consequently induce this condition. These medications mainly include Flunarizine Hydrochloride Capsules, Perphenazine Tablets, Risperidone Tablets, Tiapride Tablets, and Chlorpromazine Tablets. Detailed explanations are as follows:

1. Flunarizine Hydrochloride Capsules

Flunarizine hydrochloride belongs to calcium channel blockers. Prolonged or excessive use in children may interfere with the normal functioning of dopaminergic neurons in the brain, reduce dopamine release, lead to insufficient dopamine neurotransmitter levels, and subsequently cause symptoms resembling Parkinsonism, such as involuntary limb tremors and slow movements.

2. Perphenazine Tablets

Perphenazine is a typical antipsychotic medication that works by blocking dopamine D2 receptors in the brain. In children, its use may excessively suppress dopaminergic pathways, disrupt the balance between dopamine and other neurotransmitters, and trigger Parkinsonism manifestations such as muscle rigidity and movement retardation, especially with higher dosages increasing the risk.

3. Risperidone Tablets

Risperidone belongs to the atypical antipsychotic drugs. Although its dopamine receptor blockade is milder compared to typical agents, children's nervous systems are not yet fully developed, and its use may still affect dopamine receptor function, interfere with brain motor regulatory pathways, leading to Parkinsonism-related symptoms such as limb tremors and abnormal posture.

4. Tiapride Tablets

Tiapride has antipsychotic and sedative effects; its mechanism of action is related to influencing the dopaminergic neurotransmitter system. In children, the drug's modulation of dopamine receptors may disrupt the balance of brain neurotransmitters, triggering Parkinsonism-like reactions such as increased muscle tone and reduced movement.

5. Chlorpromazine Tablets

Chlorpromazine is a classical antipsychotic drug that powerfully blocks dopamine receptors in the brain. In children, its use easily suppresses dopaminergic nerve transmission, causing dopamine deficiency in the basal ganglia, thereby inducing symptoms of Parkinsonism such as limb tremors, delayed movements, and reduced facial expressions. The severity of these symptoms is often related to the dosage.

When administering medications to children, strictly follow medical instructions to avoid self-adjusting dosages or prolonging treatment duration. If symptoms such as limb tremors or movement abnormalities occur during medication, timely medical evaluation is necessary for prompt adjustment of the treatment plan.