How many hours after drinking alcohol can one take ibuprofen?

Common formulations of ibuprofen include tablets and capsules. Generally, a minimum interval of 24 hours should be maintained after alcohol consumption before taking ibuprofen. If only a small amount of alcohol was consumed and there is no discomfort, this interval may be shortened to 12 hours, but caution and close observation are still necessary. Detailed explanation is as follows:

Alcohol entering the body is metabolized by the liver, and complete metabolism usually takes about 24 hours. Ibuprofen is also metabolized by the liver, and taking it shortly after alcohol consumption increases the liver's metabolic burden, potentially causing liver damage. Additionally, it may irritate the gastric mucosa, increasing the risk of stomach pain and gastrointestinal bleeding, especially in individuals with pre-existing gastrointestinal weakness, who may experience adverse reactions more easily.

If only a small amount of alcohol was consumed—for example, less than 50 ml of low-alcohol beverage—and there are no symptoms such as dizziness or nausea, the metabolism of alcohol may be faster, allowing ibuprofen to be considered after 12 hours. However, even with a 12-hour interval, it is important to monitor for any abnormalities after taking the medication, such as abdominal pain or palpitations. If any discomfort occurs, discontinue the medication immediately to prevent more serious complications.

Before taking ibuprofen, ensure that the alcohol has been mostly metabolized, and avoid taking the medication on an empty stomach. If severe symptoms such as headache or fever occur after drinking, self-medication is not recommended, and prompt medical attention should be sought.