How long after taking acetaminophen can I take ibuprofen?

Sep 02, 2025 Source: Cainiu Health

Dr. Ren Yi

Introduction

Common formulations of acetaminophen and ibuprofen include tablets. Under normal circumstances, ibuprofen should not be taken until 4–6 hours after taking acetaminophen. Medications should be used as directed by a physician. When alternating between the two medications, neither should be taken more than four times within 24 hours, and the total duration of medication use should not exceed three days. Patients with severe liver or kidney disease, or gastrointestinal disorders should consult a physician before alternating between these medications.

Common formulations of acetaminophen and ibuprofen include tablets. Generally, you should wait 4-6 hours after taking acetaminophen before taking ibuprofen. Medications should be used according to medical advice. Detailed explanations are as follows:

When conventional formulations of acetaminophen are taken within the recommended dosage range, and there is no severe liver or kidney dysfunction, ibuprofen can be taken 4 hours after acetaminophen administration to relieve mild to moderate pain or low-grade fever. At this time, acetaminophen has generally completed initial metabolism, thereby reducing the risk of drug accumulation in the body.

If the acetaminophen taken is in an extended-release formulation, which is released slowly and takes longer to metabolize, or if the dose approaches the maximum daily recommended limit, or if there is mild liver or kidney insufficiency, or if it is necessary to relieve high fever or more severe pain, a 6-hour interval should be maintained before taking ibuprofen. This allows sufficient time for acetaminophen metabolism and reduces the risk of drug accumulation and potential liver or kidney damage.

Alternating between these two medications should not exceed four times within 24 hours, and the total duration of medication use should not exceed three days. Patients with severe liver or kidney disease or gastrointestinal disorders should consult a physician before alternating between these medications. Alcohol consumption should be avoided during medication use to prevent additional strain on the liver and kidneys. If symptoms do not improve or worsen after medication, prompt medical attention is necessary to determine the underlying cause; prolonging medication use or increasing the dosage without guidance should be avoided.

View All

What medication should I take for a sore throat?

Under normal circumstances, the throat refers to the pharynx. Sore throat may be related to factors such as dry environment, excessive voice use, tonsillitis, pharyngitis, and epiglottitis. Medications such as Cefradine Capsules, Paracetamol Tablets, and Compound Chlorhexidine Gargle may be taken as directed by a physician to relieve discomfort. To prevent symptoms of sore throat, it is important to maintain good oral hygiene, including regular tooth brushing and flossing, to prevent bacterial growth.