What is the difference between ibuprofen tablets and ibuprofen sustained-release capsules?
Sep 10, 2025
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Under normal circumstances, although ibuprofen tablets and ibuprofen sustained-release capsules share the same main active ingredient, they differ in terms of onset time, duration of action, applicable symptoms, drug release mechanism, and trends in blood concentration levels. In addition, neither medication should be taken in excessive amounts or abused over a prolonged period. Patients suffering from gastrointestinal disorders, kidney disease, hyperthyroidism, hypothyroidism, or other related conditions should exercise caution.
Generally, although ibuprofen tablets and ibuprofen sustained-release capsules share the same main ingredient, they differ in terms of onset time, duration of action, indications, drug release patterns, and trends in blood concentration levels. Detailed comparisons are as follows:
1. Onset Time
After entering the body, ibuprofen tablets dissolve and are absorbed relatively quickly, allowing the drug to rapidly enter the bloodstream. Pain-relieving and fever-reducing effects typically begin within 30 minutes to 1 hour after administration, making them suitable for situations requiring rapid symptom relief. In contrast, ibuprofen sustained-release capsules use a special formulation technology that slows drug release, resulting in a slower entry into the bloodstream and a longer onset time, generally taking about 1 to 2 hours before effects become noticeable.
2. Duration of Action
The effects of ibuprofen tablets last for a shorter duration, approximately 4 to 6 hours, with the therapeutic effect gradually diminishing as the drug is metabolized. Ibuprofen sustained-release capsules prolong the duration of action through gradual drug release, maintaining effectiveness for up to 12 hours. This provides longer-lasting control of pain or fever and reduces the recurrence of symptoms.
3. Indications
Due to its rapid onset, ibuprofen tablets are more suitable for short-term, acute symptoms such as sudden headaches, toothaches, or fever caused by acute colds or influenza, effectively relieving immediate discomfort. Because of its prolonged effect, ibuprofen sustained-release capsules are more appropriate for chronic pain relief, such as joint pain caused by arthritis or persistent pain due to lumbar muscle strain, helping to reduce symptom recurrence and improve patient comfort.
4. Drug Release Mechanism
After entering the gastrointestinal tract, ibuprofen tablets rapidly disintegrate and release the drug, which quickly disperses within the gastrointestinal tract before being absorbed into the bloodstream. Ibuprofen sustained-release capsules contain the drug in the form of particles or pellets coated with a special layer that enables controlled drug release at a predetermined rate, preventing a large amount of drug from being released within a short period.
5. Trends in Blood Concentration Levels
Because of its rapid release and absorption, ibuprofen tablets cause drug concentrations in the body to reach peak levels quickly, followed by a gradual decline due to metabolism, resulting in significant fluctuations in blood concentration. Ibuprofen sustained-release capsules release the drug slowly, allowing blood drug concentrations to remain relatively stable over a longer period, avoiding sharp increases or decreases in concentration and minimizing the effects of such fluctuations.
In addition, neither medication should be taken in excessive amounts or used long-term without medical supervision. Patients with gastrointestinal disorders, kidney disease, hyperthyroidism, hypothyroidism, or other related conditions should consult a physician before use. If nausea, vomiting, rash, or other adverse reactions occur after taking the medication, discontinue use immediately and seek medical attention. Both medications are intended for symptomatic treatment, and if symptoms persist, the underlying cause should be promptly investigated.
