What are the top three best medications for treating rheumatoid arthritis?

Generally speaking, there is no single "best" medication for treating rheumatoid arthritis. The appropriate drugs should be selected based on individual conditions. Commonly used medications include methotrexate tablets, leflunomide tablets, adalimumab injection, ibuprofen sustained-release capsules, and hydroxychloroquine tablets. If in doubt, it is recommended to seek medical advice promptly. Detailed analysis is as follows:

1. Methotrexate Tablets: This is a disease-modifying antirheumatic drug (DMARD) that works by inhibiting cell proliferation, helping to slow down joint damage. It is a foundational treatment for rheumatoid arthritis. It should be taken weekly at a fixed dose as prescribed, with regular monitoring of blood counts and liver and kidney function.

2. Leflunomide Tablets: Possessing anti-inflammatory and immunosuppressive effects, this medication modulates immune responses and reduces joint inflammation. It is suitable for patients who are intolerant to methotrexine. It should be taken daily at the same time each day. Liver function and white blood cell count should be monitored, especially during initial treatment.

3. Adalimumab Injection: A biologic agent that specifically binds to tumor necrosis factor (TNF), rapidly relieving joint swelling and pain while improving joint function. It is indicated for patients with moderate to severe active disease. Administered via subcutaneous injection, screening for infection risks (e.g., infection) is required before starting treatment.

4. Ibuprofen Sustained-Release Capsules: A nonsteroidal anti-inflammatory drug (NSAID) that quickly alleviates joint pain and inflammatory responses. The sustained-release formulation prolongs the drug's effect, requiring only two doses per day. Long-term or excessive use should be avoided to prevent gastrointestinal side effects.

5. Hydroxychloroquine Tablets: Helps regulate immune function and reduce joint inflammation, while also providing protection against photosensitivity. It is suitable for patients with associated skin lesions. Dosage should be calculated daily according to body weight, with regular eye examinations to monitor retinal health.

Medication use should follow an individualized approach, often involving combination therapy. Patients must strictly adhere to medical instructions and should not adjust dosages or discontinue medications on their own. Regular follow-up tests—including inflammatory markers and joint imaging—are necessary to evaluate treatment effectiveness. If symptoms such as rash, fever, or abnormal liver or kidney function occur, medical attention should be sought immediately to adjust the treatment plan.