What tests are needed before receiving the quadrivalent HPV vaccine?
Nov 05, 2025
Source: Cainiu Health
Dr. Zhang Lu
Introduction
Examinations generally required before receiving the quadrivalent HPV vaccine may include HPV virus testing, cervical cytology examination, routine blood test, coagulation function test, and screening for infectious diseases. These tests help determine whether there is an existing HPV infection, particularly the high-risk types (types 16 and 18) and low-risk types (types 6 and 11) covered by the quadrivalent vaccine, thereby clarifying the individual's infection status prior to vaccination.
Before receiving the quadrivalent HPV vaccine, recommended examinations generally include HPV virus testing, cervical cytology testing (such as TCT), complete blood count (CBC), coagulation function tests, and infectious disease screening. Specific details are as follows:
1. HPV virus testing: This test involves collecting samples to determine whether there is an existing HPV infection, particularly the high-risk types (types 16 and 18) and low-risk types (types 6 and 11) covered by the quadrivalent vaccine. It helps clarify the individual's infection status before vaccination, guiding the appropriateness of vaccination and identifying future prevention priorities.
2. Cervical cytology examination: Also known as cervical TCT testing, this involves collecting cervical cells to examine their morphology, helping detect cervical inflammation, precancerous lesions, or cancer cells. Assessing cervical health ensures that individuals do not rely solely on vaccination when undiagnosed cervical abnormalities are present, thus avoiding delays in timely intervention.
3. Complete blood count (CBC): This evaluates levels of white blood cells, red blood cells, platelets, and other blood components. It helps identify acute infections (e.g., elevated white blood cells indicating bacterial infection), anemia, or coagulation disorders. Ensuring overall good health reduces the risk of adverse reactions after vaccination.
4. Coagulation function testing: This assesses indicators such as prothrombin time (PT) and activated partial thromboplastin time (aPTT) to determine whether blood clotting functions normally. It helps prevent prolonged bleeding or hematoma formation at the injection site due to coagulation disorders, ensuring the safety of the vaccination process.
5. Infectious disease screening: Includes testing for hepatitis B virus, hepatitis C virus, syphilis, and HIV. These tests help identify existing infectious diseases, which is important both for evaluating whether the individual’s immune system is fit for vaccination and for enabling vaccination centers to implement proper protective and disinfection measures to prevent cross-infection.
The specific tests required may vary depending on age and personal medical history (e.g., sexual activity, previous illnesses). Follow the recommendations of the vaccination provider. Before vaccination, it is essential to inform the doctor about any history of allergies or current medications to avoid contraindications.
