Should otitis media be treated with amoxicillin or roxithromycin?

Nov 06, 2025 Source: Cainiu Health

Dr. Lu Cheng

Introduction

Amoxicillin is usually preferred in cases of otitis media caused by susceptible bacteria, as these bacteria are highly sensitive to amoxicillin. The drug can rapidly inhibit bacterial growth and control the progression of inflammation. Amoxicillin achieves high concentrations in the middle ear cavity and acts relatively quickly. It is suitable for most patients without a history of drug allergies, especially children with acute bacterial otitis media, for whom it is commonly the first-line treatment.

　　The choice of medication for otitis media generally depends on the type of infection and the patient's condition. Amoxicillin is usually the first-line treatment for otitis media caused by bacterial infections. If the patient is allergic to amoxicillin or if the bacteria are resistant, roxithromycin may be considered instead. In case of uncertainty, it is recommended to consult a healthcare provider in advance. Detailed analysis is as follows:

　　Amoxicillin is typically preferred when otitis media is caused by bacteria sensitive to this antibiotic. These bacteria are highly susceptible to amoxicillin, which can rapidly inhibit bacterial growth and control the progression of inflammation. Amoxicillin achieves high concentrations in the middle ear cavity and acts relatively quickly, making it suitable for most patients without a history of drug allergy, especially children with acute bacterial otitis media, for whom it is often the first-choice drug.

　　Roxithromycin is an alternative option commonly used in patients allergic to penicillin-class drugs (such as amoxicillin) or when the bacteria have developed resistance to amoxicillin. Roxithromycin belongs to the macrolide class of antibiotics and works by inhibiting bacterial protein synthesis, making it effective against certain resistant strains or individuals with allergies. However, its antimicrobial spectrum differs from that of amoxicillin, so a physician must determine its appropriateness based on the specific infecting pathogen.

　　During antibiotic treatment, it is essential to strictly follow medical instructions regarding dosage and duration—do not stop taking the medication or adjust the dose without guidance. Monitor symptoms after starting treatment; if rashes, nausea, or other adverse reactions occur, or if symptoms worsen, seek medical attention promptly.

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Can Chlorphenamine Maleate Tablets be taken together with Roxithromycin Capsules?

In general, chlorphenamine, phenylpropanolamine and paracetamol tablets can be taken together with roxithromycin capsules, but only as directed by a physician. During treatment, drink plenty of warm water to promote drug metabolism and excretion. Avoid alcohol consumption, as it may increase gastrointestinal irritation and potentially affect drug efficacy. If symptoms such as nausea, vomiting, or rash occur, discontinue the medication immediately and seek medical attention.