Can ankylosing spondylitis lead to tuberculosis?
Nov 07, 2025
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Ankylosing spondylitis itself does not directly cause tuberculosis, but abnormal immune function or long-term medication use may increase the risk of infection. These two conditions are different types of diseases and have no direct causal relationship. Most patients only present with inflammation of the spine and joints, without severe immune impairment. In individuals without a history of tuberculosis exposure or use of immunosuppressive drugs, the probability of developing tuberculosis is not significantly different from that of the general population.
Generally, ankylosing spondylitis itself does not directly cause tuberculosis; however, abnormal immune function or long-term medication use may increase the risk of infection. If concerned, it is recommended to consult a healthcare provider early. Detailed analysis is as follows:
The two conditions are different in nature and have no direct causal relationship. Most patients only experience inflammation of the spine and joints without severe immune impairment. In the absence of tuberculosis exposure history or immunosuppressive drug use, their risk of developing tuberculosis is similar to that of the general population, so excessive concern is unnecessary.
However, some patients who require long-term use of immunosuppressive medications due to disease management may experience reduced immunity, increasing susceptibility to infection. Additionally, those exposed to tuberculosis sources in daily life may face higher infection risks. Moreover, during active disease phases, immune system dysregulation may indirectly elevate infection risk; symptoms such as cough and low-grade fever should raise suspicion.
Daily preventive measures should be taken to avoid contact with infectious sources. Patients on long-term medication should regularly monitor immune function, and any suspected symptoms of tuberculosis should be promptly evaluated.
