What are the differences between flupentixol-melitracen tablets and doxepin?
Nov 07, 2025
Source: Cainiu Health
Dr. Yang Ziqi
Introduction
The common formulation of doxepin is tablet. Generally, the main differences between flupentixol-melitracen tablets and doxepin include different drug classes, different mechanisms of action, different indications, different onset speeds, and different profiles of adverse reactions. When taking either medication, dosage adjustments should follow medical advice; do not adjust or discontinue the dose on your own.
Doxepin is commonly available in tablet form. Generally, the main differences between flupentixol-melitracen tablets and doxepin include differences in drug class, mechanism of action, indications, onset of action, and distinct profiles of adverse reactions. The detailed analysis is as follows:
1. Different Drug Classes
Flupentixol-melitracen tablets are a combination preparation containing flupentixol and melitracen; doxepin is a single-component drug belonging to the tricyclic antidepressants.
2. Different Mechanisms of Action
Flupentixol exerts antipsychotic effects by blocking dopamine D2 receptors, while melitracen produces antidepressant effects by inhibiting the reuptake of serotonin and norepinephrine. Doxepin primarily works by inhibiting the reuptake of serotonin and norepinephrine, as well as blocking histamine H1 and muscarinic M receptors.
3. Different Indications
Flupentixol-melitracen tablets are indicated for mild to moderate depression and anxiety, neurasthenia, etc.; doxepin is indicated for various types of depression and can also be used to treat allergic pruritus.
4. Different Onset Speeds
Flupentixol-melitracen tablets have a relatively rapid onset of action, with effects typically seen within 1–2 weeks; doxepin has a slower onset, with therapeutic effects gradually emerging after 2–4 weeks.
5. Different Profiles of Adverse Reactions
Flupentixol-melitracen may cause extrapyramidal symptoms, insomnia, etc.; doxepin is more likely to cause dry mouth, drowsiness, constipation, blurred vision, and other anticholinergic and antihistaminic effects.
When taking either medication, dosage adjustments must follow medical advice—do not adjust or discontinue the dose on your own. Avoid alcohol during treatment, seek medical attention promptly if severe discomfort occurs, and adjust the treatment plan according to disease progression.
