What does it mean when the lesion disappears after a cervical biopsy?

Nov 15, 2025 Source: Cainiu Health

Dr. Zhang Lu

Introduction

In general, the disappearance of lesions after cervical biopsy may be due to immune clearance by the body, limitations in sampling during examination, regression of low-risk HPV infection, healing of cervicitis, or reversal of cervical intraepithelial neoplasia. If abnormal bleeding or other discomfort occurs, it is recommended to promptly return for a follow-up visit at a qualified medical institution. In daily life, maintain cleanliness and dryness of the external genitalia, and avoid unhygienic sexual practices.

In general, the disappearance of cervical lesions after a cervical biopsy may be due to immune clearance by the body, limitations in sampling during examination, clearance of low-risk HPV infection, healing of cervicitis, or regression of cervical intraepithelial neoplasia. If abnormal bleeding or other discomfort occurs, it is recommended to promptly return to a qualified hospital for follow-up. Specific causes are analyzed as follows:

1. Immune Clearance by the Body

After recognizing abnormal cervical cells, the body's immune system activates mechanisms to gradually eliminate these cells, leading to lesion regression. Maintaining regular sleep patterns (avoiding late nights), eating a balanced diet rich in protein, and engaging in moderate exercise such as brisk walking can help enhance immune function.

2. Sampling Limitations During Examination

A biopsy involves taking only a small tissue sample, which may miss the core area of the lesion; thus, residual lesions might not be detected upon re-examination. Follow your doctor’s advice to undergo regular cervical TCT and HPV testing. Repeat biopsies may be necessary when needed to ensure comprehensive evaluation.

3. Clearance of Low-Risk HPV Infection

Mild cervical changes caused by low-risk HPV infections may resolve spontaneously once the virus is cleared. Under medical guidance, treatments such as recombinant human interferon α2b gel, Baofukang suppositories, or Kangongyan tablets may be used. Personal hygiene should be maintained to prevent cross-infection.

4. Healing of Cervicitis

Pseudo-lesions caused by inflammatory stimulation can resolve as inflammation subsides and cervical tissue returns to normal. Under medical supervision, medications such as cefuroxime axetil tablets, azithromycin dispersible tablets, or Gynecological Qianjin tablets may be prescribed. Avoid tub baths during treatment.

5. Regression of Cervical Intraepithelial Neoplasia (CIN)

Mild cervical intraepithelial neoplasia may naturally regress, with abnormal cells gradually transforming back into normal cells. Under medical guidance, treatments such as recombinant human interferon α2a suppositories, Gongyanping capsules, or levofloxacin tablets may be used. Regular follow-ups are essential, and cervical conization may be considered if progression is observed.

In daily life, maintain cleanliness and dryness of the external genitalia and avoid unhygienic sexual practices. Have a stable sexual partner to reduce the risk of HPV infection. Quit smoking and limit alcohol consumption to maintain a healthy lifestyle. Strictly adhere to medical advice for regular gynecological examinations to monitor cervical health.

View All

What does cervical cancer screening include?

In general, cervical cancer screening includes items such as HPV testing, cytology examination, colposcopy, cervical biopsy, and cervical DNA testing. The selection of cervical cancer screening methods varies depending on individual circumstances, and appropriate screening methods can be chosen based on a doctor's recommendations and specific medical conditions. At the same time, regular cervical cancer screening is one of the important measures for preventing cervical cancer.

View Full Answer

After a cervical biopsy, is it still necessary to have an HPV test?

Regardless of the cervical biopsy results, it is necessary to perform HPV (human papillomavirus) testing, as there is a significant association between the two. Conducting both tests together facilitates diagnosis and analysis, enabling a more reasonable treatment plan. However, the tests should be spaced one week apart and performed 3–7 days after menstruation ends to avoid infection during the menstrual period and potential impact on diagnostic accuracy.

View Full Answer

How to Prevent the Occurrence of Cervical Cancer Through Screening

Cervical cancer can be prevented through screening methods such as cervical cytology (Pap smear), human papillomavirus (HPV) testing, colposcopy, cervical biopsy, and liquid-based thin-layer cytology. In daily life, it is important to maintain external genital hygiene while avoiding excessive vaginal douching, which may disrupt the balance of normal bacterial flora. Additionally, using condoms during sexual intercourse can help reduce the risk of HPV infection.

View Full Answer

How to Confirm if it's Bleeding from Cervical Cancer

In general, methods such as colposcopy, cervical smear test, cervical biopsy, imaging examinations, and blood tests can be used to determine whether the bleeding is caused by cervical cancer. The specific details are as follows: 1. Gynecological examination: The doctor will directly observe the appearance of the cervix to check for ulcers, masses, or abnormal color changes.