Will there be a rebound after discontinuing atomoxetine?

In general, whether rebound occurs after discontinuation of atomoxetine depends on the disease control status, method of discontinuation, and individual differences. The details are as follows:

When the condition has been stably controlled for a sufficient treatment duration, and the medication is gradually tapered and discontinued under medical supervision, individuals with good metabolic and adaptive capacity typically do not experience symptom rebound after stopping atomoxetine. In these patients, symptoms have been effectively controlled over the long term, and gradual dose reduction allows the body adequate time to adjust. After discontinuation, maintaining healthy lifestyle modifications can help sustain stable symptom control.

However, if the medication is stopped abruptly before the condition has stabilized, or in patients with severe baseline symptoms or strong dependence on the drug, rebound symptoms are more likely to occur. Sudden discontinuation may disrupt neurotransmitter balance, leading to recurrence or even worsening of original symptoms such as inattention and impulsivity. Some individuals may also experience dizziness, mood swings, or other discomforts.

Dosage adjustments during discontinuation must strictly follow medical instructions—patients should never alter the dose on their own. Maintain regular sleep patterns and a balanced diet, and avoid excessive fatigue and emotional stress. Family members should assist in recording daily conditions and symptom changes. Regular follow-up visits should be attended with a healthcare provider, and any abnormalities should be promptly reported to ensure a smooth transition through the discontinuation period.