Which medication is better for adolescent depression, quetiapine or amisulpride?

Quetiapine is commonly available in tablet form, while amisulpride is available in tablets, injections, and other formulations. Generally speaking, there is no definitive answer to the question of "which medication—quetiapine or amisulpride—is better for treating adolescent depression." Both quetiapine and amisulpride are antipsychotic medications and are typically not first-line treatments for adolescent depression, although they may be used in specific clinical situations. If medication is needed, it should only be taken under the guidance of a physician. The detailed analysis is as follows:

Quetiapine is an atypical antipsychotic that primarily works by regulating the balance of neurotransmitters such as dopamine and serotonin in the brain. It is mainly indicated for the treatment of schizophrenia, effectively improving both positive symptoms (e.g., hallucinations, delusions, disorganized thinking) and negative symptoms (e.g., emotional blunting). It can also be used in the management of bipolar disorder, helping regulate symptoms such as excessive speech, impulsivity, and irritability during manic episodes, as well as low mood during depressive episodes. Additionally, under certain circumstances, it may be used as an adjunctive treatment for severe insomnia or anxiety disorders, but must be strictly administered according to medical instructions.

Amisulpride is also an atypical antipsychotic, primarily acting through selective modulation of the dopaminergic nervous system, with high affinity for dopamine D2 and D3 receptors. Its main indication is schizophrenia, particularly effective in controlling positive symptoms such as hallucinations and delusions, and it can also improve negative symptoms like social withdrawal and reduced motivation. It is also used in the treatment of manic episodes in bipolar disorder, helping stabilize mood and reduce impulsive behaviors. Amisulpride has relatively less impact on cognitive function, and dosing should be individualized based on symptom severity and patient tolerance.

In daily life, it is important to create a supportive and understanding environment, maintain open communication with adolescents, and actively listen to their inner thoughts. Maintaining regular sleep patterns and a balanced diet ensures adequate nutrition and supports healthy physical and psychological development. Encouraging participation in hobbies and social activities helps divert attention and alleviate emotional stress. Medication must be taken strictly as prescribed, with regular follow-up appointments; any behavioral or physical abnormalities should prompt timely review and adjustment of the treatment plan.