10 Early Signs of Depression in Adolescence

Nov 24, 2025 Source: Cainiu Health

Dr. Zhang Baohua

Introduction

There is no such thing as "10 early signs of adolescent depression." Early signs of depression during adolescence may include abnormal emotional states, changes in learning behaviors, withdrawal from social activities, unusual physiological responses, and cognitive distortions. It is important to closely monitor psychological changes in teenagers and to detect and intervene early. If these symptoms persist for more than two weeks and affect daily functioning, prompt medical consultation is recommended.

There is no such thing as "10 early warning signs of adolescent depression." However, early signs of depression during adolescence may include abnormal emotional states, changes in learning behaviors, social withdrawal, unusual physiological responses, and cognitive distortions. It is important to closely monitor psychological changes in teenagers and to identify and intervene as early as possible. If these symptoms persist for more than two weeks and interfere with daily functioning, prompt medical consultation is recommended.

1. Abnormal emotional state: Frequent feelings of sadness, irritability, or anger; loss of interest in activities previously enjoyed; easily upset or tearful over minor issues; significant mood swings that are difficult to self-regulate; prolonged periods of negative emotions.

2. Changes in learning behavior: Sudden decline in academic performance; difficulty concentrating; procrastination and careless completion of homework; frequent daydreaming in class; loss of confidence in studies; even avoidance behaviors such as skipping school or developing a strong aversion to learning.

3. Social withdrawal: Gradually distancing from peers and friends; refusing to participate in group activities; unwillingness to communicate or interact; preference for isolation; avoiding social situations once enjoyed; increasingly distant interpersonal relationships.

4. Abnormal physiological responses: Sleep disturbances such as insomnia, early awakening, or excessive sleeping; noticeable changes in appetite leading to weight gain or loss; persistent fatigue, dizziness, or headaches; reduced attention and memory; physical discomfort without identifiable organic cause.

5. Cognitive distortions: Frequent self-blame and low self-esteem; excessive denial of self-worth; feelings of hopelessness and pessimism about the future; slowed thinking; overly negative or extreme viewpoints; and in severe cases, talk or thoughts related to suicide.

Maintain open communication with adolescents, actively listen to their inner thoughts, and offer respect and understanding—avoid excessive criticism or pressure. Encourage participation in enjoyable activities and regular physical exercise, foster a warm and supportive family environment, and help build a positive and optimistic mindset.

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Which medication is better for adolescent depression, quetiapine or amisulpride?

Quetiapine is commonly available in tablet form, while amisulpride is available in tablets, injections, and other formulations. Generally speaking, it is not appropriate to ask which drug—quetiapine or amisulpride—is better for treating adolescent depression. Both quetiapine and amisulpride are antipsychotic medications and are typically not first-line treatments for adolescent depression, although they may be used in specific circumstances.

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What are the symptoms of depression in adolescents?

Symptoms of depression in adolescents can generally be observed through persistent low mood, declining academic performance, reduced interest in social activities, abnormal behavior patterns, and negative self-perception. They often appear unhappy, lose interest in games, sports, or social activities they once enjoyed, become easily tearful, irritable, or prone to outbursts over minor issues, and experience frequent mood swings that are difficult to regulate on their own.