How long after stopping escitalopram oxalate tablets can one start taking sertraline?
Nov 21, 2025
Source: Cainiu Health
Dr. Zhang Baohua
Introduction
After discontinuing escitalopram oxalate tablets, wait 1–2 weeks before starting sertraline. Both drugs are selective serotonin reuptake inhibitors; switching directly between them increases the risk of serotonin syndrome, and an interval period helps reduce this risk. If severe dizziness, palpitations, or worsening mood fluctuations occur during the transition, seek medical attention promptly.
After discontinuing escitalopram oxalate tablets, it is necessary to wait 1–2 weeks before starting sertraline. Both medications belong to the selective serotonin reuptake inhibitor (SSRI) class; switching directly between them increases the risk of serotonin syndrome, and an adequate interval helps reduce this risk. If severe dizziness, palpitations, or worsened mood fluctuations occur during the transition, prompt medical attention is recommended.
Escitalopram oxalate tablets and sertraline have similar mechanisms of action, both exerting antidepressant effects by regulating serotonin levels in the brain. Switching directly may lead to overlapping drug effects, potentially causing serotonin excess, with symptoms such as nausea, vomiting, elevated blood pressure, or even confusion.
A 1–2 week washout period allows the body to gradually metabolize and eliminate escitalopram oxalate, minimizing residual drug interactions with sertraline. This interval also enables monitoring of clinical changes after discontinuation, providing a basis for appropriate sertraline dosing and helping prevent relapse due to medication changes.
Maintain regular sleep patterns during the transition, avoid emotional stress and excessive fatigue, and follow a light, easily digestible diet. Strictly adhere to medical instructions regarding the tapering schedule of escitalopram and the initial dose of sertraline—do not shorten the interval or adjust doses on your own.
