How long should sertraline be taken at a frequency of one tablet every two days before switching to one tablet every three days?

Nov 24, 2025 Source: Cainiu Health

Dr. Zhang Baohua

Introduction

If the condition remains stable after taking one tablet every two days (such as normal mood, sleep, and social functioning), and this stability has been maintained for 2–3 consecutive months without significant physical discomfort (e.g., dizziness, nausea), the doctor may suggest attempting to reduce the dosage further to one tablet every three days. During this phase, it is essential to closely monitor for any fluctuations in symptoms to ensure that there is no relapse following the dose reduction.

Under normal circumstances, sertraline taken every two days should be continued until the condition is stable and the body has adapted before considering a change to every three days. The specific duration varies and must be evaluated by a doctor—there is no fixed standard. If in doubt, it is recommended to seek medical advice in advance. Detailed analysis is as follows:

If the condition remains stable after taking sertraline every two days (e.g., mood, sleep, and social functioning are all normal), and this stability has been maintained for 2–3 consecutive months without significant side effects (such as dizziness or nausea), the doctor may consider adjusting the regimen to every three days. During this period, close monitoring is essential to ensure that symptoms do not rebound following dose reduction.

If symptoms continue to fluctuate during the every-other-day dosing period (e.g., low mood, increased anxiety), or if the body has not yet fully adapted to the current dose (e.g., persistent fatigue, changes in appetite), the duration of taking sertraline every two days should be extended. Only after the condition stabilizes and the body tolerates the medication well should the doctor reassess whether transitioning to every three days is appropriate. Do not rush to reduce the dosage.

Dose reduction of sertraline must strictly follow medical guidance; do not shorten the dosing interval on your own. Keep a record of symptom changes and physical responses during dose reduction, and seek medical attention promptly if any abnormalities occur. Attend regular follow-up appointments so the doctor can adjust the treatment plan based on recovery progress.

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