Does midazolam infusion need to be protected from light?

Under normal circumstances, when midazolam is administered via infusion pump, the undiluted original solution must be strictly protected from light during storage. However, once diluted and during use or short-term storage, additional light protection is not required. In case of any abnormalities, medical personnel should be contacted promptly. Detailed explanations are as follows:

Midazolam injection must be strictly protected from light in its undiluted, original form because its chemical properties are light-sensitive. Exposure to sunlight may cause drug degradation, leading to changes in color or decreased concentration, thereby affecting efficacy. For example, after one month of improper storage without light protection, the solution may turn yellow; after four months, a reduction in concentration may occur.

However, if the solution has been properly diluted with 0.9% sodium chloride solution or 5% glucose solution, and is either being used or stored short-term, additional light protection is unnecessary. Studies have shown that when diluted solutions are stored in polypropylene syringes at temperatures between 5°C and 30°C for up to 10 days, no significant change in drug concentration occurs, indicating a high level of safety for short-term clinical use.

Strict adherence to the drug’s package insert and medical instructions is essential. Before administration, inspect the solution for discoloration, turbidity, or foreign particles; discontinue use immediately if any abnormalities are detected. During infusion, avoid direct sunlight exposure to the infusion tubing to ensure medication safety.