Can rupatadine tablets and perampanel tablets be taken together?

Nov 24, 2025 Source: Cainiu Health
Dr. Zhang Baohua
Introduction
If a patient simultaneously presents symptoms of allergic diseases and epilepsy—for example, allergic rhinitis accompanied by epileptic seizures—a physician may, after comprehensive evaluation, determine that combination therapy can effectively control both conditions separately. In such cases, rupatadine tablets can alleviate allergic reactions while perampanel tablets help prevent epileptic seizures. The physician will clearly specify the dosage and administration schedule for both medications to avoid potential interactions. Under these circumstances, the two drugs may be taken together as directed by the medical provider.

Generally, whether rupatadine tablets and perampanel tablets can be taken together should be determined by a doctor after evaluation. They may be used in combination if clinically necessary and no contraindications exist, but are not recommended for individuals with specific health conditions. If in doubt, it is advisable to consult a healthcare provider in advance. Detailed analysis is as follows:

If a patient simultaneously suffers from allergic diseases and epilepsy—for example, allergic rhinitis accompanied by epileptic seizures—a physician may determine, after comprehensive assessment, that combined use of the two medications would effectively control both conditions. Rupatadine tablets help alleviate allergic reactions, while perampanel tablets help prevent seizures. The doctor will clearly specify the dosage and timing of each medication to avoid potential interactions. In such cases, the drugs may be taken together as directed by the physician.

However, if a patient has severe liver or kidney impairment, a history of hypotension, or experiences central nervous system depression symptoms such as drowsiness, dizziness, or difficulty concentrating after taking either drug, combining them may increase metabolic burden on the body or elevate the risk of adverse effects. In these situations, concurrent use is not recommended, and the treatment plan should be adjusted by a physician.

Before taking these medications, patients should inform their doctor about their complete medical history, medication history, and any previous adverse reactions; strictly follow the prescribed dosage and schedule without self-adjusting; and monitor their physical response during treatment. If any discomfort occurs, discontinue the medication immediately and seek medical advice promptly.