Can doxepin hydrochloride tablets and citalopram be taken together?
Nov 24, 2025
Source: Cainiu Health
Dr. Zhang Baohua
Introduction
Common formulations of citalopram include tablets and oral solutions. Generally, doxepin hydrochloride tablets and citalopram should not be taken together. During antidepressant treatment, medications must be used strictly as prescribed and separately; do not combine drugs or adjust dosages on your own. If the current medication appears ineffective, promptly consult your attending physician for evaluation and possible adjustment of the treatment plan by a healthcare professional.
Citalopram is commonly available in tablet and oral solution formulations. Generally, doxepin hydrochloride tablets and citalopram should not be taken together. The detailed explanation is as follows:
Doxepin hydrochloride tablets belong to the class of tricyclic antidepressants, while citalopram is a selective serotonin reuptake inhibitor. These two medications have different mechanisms of action, and their combined use significantly increases the risk of serotonin syndrome. Doxepin hydrochloride inhibits serotonin reuptake, whereas citalopram selectively blocks the serotonin transporter. When used together, they can cause abnormally high levels of serotonin in the body, potentially leading to severe symptoms such as hyperthermia, muscle rigidity, and confusion. Additionally, this combination may increase the burden on the central nervous system and cardiovascular system, resulting in adverse reactions like dizziness, palpitations, and abnormal blood pressure, causing multiple harmful effects on the body.
During treatment with antidepressant medications, it is essential to strictly follow medical instructions and take only the prescribed medication individually—do not self-combine drugs or adjust dosages. If the current medication appears ineffective, promptly consult your treating physician for evaluation and adjustment of the treatment plan by a healthcare professional. Maintain a regular daily routine, avoid alcohol consumption and strong tea, minimize potential drug interactions, and closely monitor your body's responses. If any unusual discomfort occurs, discontinue the medication immediately and seek medical attention.
