Can taking trazodone hydrochloride tablets cause swelling of the lips?

Under normal circumstances, taking trazodone hydrochloride tablets and having them come into contact with the lips does not directly cause lip swelling. The specific analysis is as follows:

Contact between trazodone hydrochloride tablets and the lips is not a direct cause of lip swelling. This medication primarily works after oral administration and absorption through the gastrointestinal tract. Its ingredients do not directly irritate the lip mucosa to trigger edema. If lip swelling does occur, it is usually due to other factors—for instance, an allergic reaction to the drug's components. However, such an allergy is not caused by physical contact with the lips, but rather by an immune response triggered after the drug enters the body. Other possible causes include pre-existing lip inflammation, insect bites, or exposure to other allergens; these are not directly related to the tablet touching the lips.

During regular use of this medication, if the tablet accidentally contacts the lips, simply wipe the area gently with clean water—there is no need for excessive concern. However, if symptoms such as lip swelling or rash develop after taking the medication, discontinue use immediately and seek medical attention promptly to determine whether an allergic reaction has occurred. Store the medication away from mucosal areas such as the lips and eyes. When taking the medicine, swallow it with lukewarm water to minimize unnecessary contact with mucous membranes, and pay close attention to any subtle bodily reactions to ensure safe medication use.