What are the adverse reactions of meropenem for injection?
Nov 25, 2025
Source: Cainiu Health
Dr. Wang Lei
Introduction
Under normal circumstances, meropenem for injection, as a broad-spectrum carbapenem antibiotic, may cause adverse reactions including gastrointestinal disturbances, allergic reactions, hematological abnormalities, nervous system reactions, and effects on liver and kidney function. Meropenem for injection is a prescription drug and must be used only under the guidance of a physician. Patients should fully inform their medical and medication history prior to administration.
Generally, meropenem for injection, as a broad-spectrum carbapenem antibiotic, may cause adverse reactions including gastrointestinal effects, allergic reactions, hematological abnormalities, neurological reactions, and impacts on liver and kidney function. A detailed analysis is as follows:
1. Gastrointestinal reactions: These are the most common adverse effects. Most patients experience nausea, vomiting, and diarrhea; some may develop abdominal pain or loss of appetite. Diarrhea is usually mild to moderate in severity, but in rare cases, pseudomembranous colitis may be induced, presenting as watery stools with mucus or bloody stools.
2. Allergic reactions: The severity varies widely. Mild reactions include rash, itching, and drug fever, typically appearing several days after administration. Severe cases may involve anaphylactic shock, characterized by sudden drop in blood pressure, difficulty breathing, and laryngeal edema. Immediate discontinuation of the drug and emergency treatment are required if such symptoms occur.
3. Hematological abnormalities: Some patients may develop leukopenia, neutropenia, or thrombocytopenia after using the drug, with occasional eosinophilia. These changes may lead to fatigue, increased susceptibility to infections, or bleeding tendencies. Regular monitoring of complete blood count is necessary during treatment to detect any abnormalities promptly.
4. Neurological reactions: Common symptoms include headache and dizziness, with occasional insomnia or anxiety. In patients with a history of epilepsy, renal impairment, or elderly individuals, seizures may be triggered or worsened, manifesting as limb convulsions or impaired consciousness. Strict dose control and close observation are required when administering the drug to these populations.
5. Liver and kidney function effects: A minority of patients may exhibit abnormal liver function indicators, such as elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST), accompanied by symptoms like fatigue or jaundice. In those with impaired renal function, increased serum creatinine and blood urea nitrogen levels may occur, indicating compromised drug excretion. Dosage adjustments should be made according to renal function status.
Meropenem for injection is a prescription medication and must be used under the guidance of a physician. Patients should fully disclose their medical and medication history prior to use. During treatment, cooperation with healthcare providers for necessary monitoring is essential, and any abnormalities should be promptly reported to ensure safe use of the drug.
