What are the contraindications of Pralidoxime Iodide Injection?
Nov 25, 2025
Source: Cainiu Health
Dr. Wang Lei
Introduction
Contraindications for pralidoxime iodide injection mainly include: patients allergic to this product, individuals without organophosphorus poisoning, elderly patients should use with caution, and the drug must not be used if there is any change in its physical properties. It should not be mixed with alkaline medications. This medicine is a prescription drug and must be used strictly according to the type and severity of poisoning under a doctor's guidance. During treatment, the patient’s consciousness, respiration, heart rate, and other vital signs should be closely monitored.
Contraindications for pralidoxime iodide injection mainly include: patients allergic to this product should not use it; it is contraindicated in non-organophosphorus poisoning cases; elderly patients should use with caution; do not use if the drug's physical properties have changed; and avoid mixing with alkaline medications. Specific details are as follows:
1. Contraindicated in patients allergic to this product: Some individuals may be allergic to pralidoxime iodide or its excipients. Administration may lead to allergic reactions such as rash, itching, and difficulty breathing. In severe cases, anaphylactic shock can occur, which may be life-threatening. These individuals must absolutely avoid using this medication.
2. Contraindicated in non-organophosphorus poisoning: This drug is effective only against organophosphorus pesticide poisoning and has no effect on other types of poisoning. Using it in non-organophosphorus poisoning cases will not alleviate symptoms and may increase the risk of adverse drug reactions.
3. Use with caution in elderly patients: Elderly individuals often have reduced liver and kidney function, leading to decreased capacity for drug metabolism and excretion. This increases the risk of drug accumulation and adverse effects such as dizziness, nausea, and blurred vision. If use is necessary, dosage adjustments under medical supervision and close monitoring are required.
4. Do not use if the drug’s physical properties have changed: If the solution changes color, becomes cloudy or precipitated, or if the ampoule is cracked or the label is unclear, the drug may have degraded. The active ingredient may be destroyed, rendering it ineffective for detoxification and potentially causing local irritation or systemic toxic reactions.
5. Avoid mixing with alkaline drugs: This medication easily degrades and becomes ineffective in alkaline environments. Therefore, it should not be mixed with alkaline drugs such as sodium bicarbonate or aminophylline during infusion. If combination therapy is needed, administer separately with an appropriate time interval to ensure drug stability and efficacy.
This medication is a prescription drug and must be used strictly under a physician's guidance based on the type and severity of poisoning. During treatment, closely monitor the patient’s consciousness, respiration, heart rate, and other vital signs, promptly manage any adverse reactions, and ensure safe medication use.
