What are the antidotes for organophosphate poisoning?
May 16, 2023
Source: Cainiu Health
Dr. Yang Shuwen
Introduction
In cases of organophosphorus poisoning, treatment should follow medical advice using medications such as pralidoxime iodide injection, pralidoxime chloride injection, atropine sulfate injection, and racemic anisodamine hydrochloride injection. These drugs are effective in detoxification. As each medication has different pharmacological properties, they must be used under a doctor's guidance to prevent worsening of poisoning symptoms and avoid adverse effects on the body.
In general, organophosphorus poisoning can be treated with medications such as pralidoxime iodide injection, pralidoxime chloride injection, and atropine sulfate injection. A detailed analysis is as follows:
1. Pralidoxime Iodide Injection
This medication belongs to the class of cholinesterase reactivators. It indirectly reduces the accumulation of acetylcholine and can restore acetylcholinesterase's ability to break down acetylcholine, thereby effectively treating organophosphate pesticide poisoning.
2. Pralidoxime Chloride Injection
Pralidoxime chloride injection and pralidoxime iodide injection both belong to cholinesterase reactivators and are capable of effectively breaking down acetylcholine. In cases of severe poisoning symptoms, it may be used in combination with atropine sulfate injection.
3. Atropine Sulfate Injection
This is a cholinergic nerve inhibitor that effectively antagonizes the muscarinic effects of acetylcholine, increases the body's tolerance, effectively relieves smooth muscle spasms, and reduces glandular secretions.
In addition to the above medications, racemic hyoscine hydrochloride injection may also be used. The dosage and administration of these medications should generally follow medical advice.
