What are the contraindications of aminomethylbenzoic acid?

Under normal circumstances, aminomethylbenzoic acid—a commonly used hemostatic drug—has several contraindications, including individuals with a tendency for thrombosis, those with a history of thromboembolic diseases, patients with hemophilia or similar bleeding disorders, individuals with renal insufficiency, and those allergic to the drug. A detailed analysis is as follows:

1. Individuals with a tendency for thrombosis: Aminomethylbenzoic acid exerts its hemostatic effect by inhibiting fibrinolysis. In these individuals, blood coagulability is already heightened; using this drug may accelerate thrombus formation and increase the risk of serious complications such as pulmonary embolism and cerebral infarction. Therefore, it must be strictly avoided.

2. Patients with a history of thromboembolic disease: Those who have previously experienced venous thrombosis, arterial embolism, or similar conditions still possess an underlying pathological basis for thrombosis. Using aminomethylbenzoic acid further suppresses the fibrinolytic system, potentially worsening existing clots or promoting new clot formation, thereby endangering health.

3. Patients with hemophilia or similar bleeding disorders: Bleeding in these patients is not caused by excessive fibrinolysis, but rather by deficiencies or dysfunction of clotting factors. Aminomethylbenzoic acid cannot improve coagulation function and may instead mask symptoms by suppressing fibrinolysis, leading to delayed diagnosis and specific treatments.

4. Patients with renal insufficiency: The drug is primarily excreted through the kidneys. When kidney function is impaired, excretion capacity decreases, making drug accumulation more likely. This increases the risk of adverse effects such as nausea, vomiting, and dizziness, while also placing additional metabolic strain on the kidneys, which may hinder disease management.

5. Individuals allergic to the drug: People allergic to aminomethylbenzoic acid or any component of its formulation may experience allergic reactions such as rash, itching, or dyspnea after administration. In severe cases, anaphylactic shock may occur; thus, this constitutes an absolute contraindication.

Aminomethylbenzoic acid is a prescription medication and must be used only under medical supervision. Patients should fully disclose their medical history before treatment and closely monitor bodily responses during therapy to ensure safe use.