Which anti-inflammatory drug is the first choice for purulent tonsillitis?
Nov 27, 2025
Source: Cainiu Health
Dr. Ren Yi
Introduction
Tonsillar abscess is usually caused by bacterial infection. The first-choice anti-inflammatory medication should be determined based on the type of pathogen, patient's allergy history, and severity of the condition. Commonly used anti-inflammatory drugs include penicillin V potassium tablets, amoxicillin capsules, cefuroxime axetil tablets, azithromycin dispersible tablets, and clindamycin capsules. A detailed analysis is as follows:
Purulent tonsillitis is usually caused by bacterial infection. The choice of first-line anti-inflammatory medication should be based on the type of pathogen, patient's allergy history, and severity of the condition. Commonly used anti-inflammatory drugs include Penicillin V Potassium Tablets, Amoxicillin Capsules, Cefuroxime Axetil Tablets, Azithromycin Dispersible Tablets, and Clindamycin Capsules. A detailed analysis is as follows:
1. **Penicillin V Potassium Tablets**: As a penicillin-class antibiotic, it has high sensitivity against common bacteria causing purulent tonsillitis (e.g., streptococci) and is one of the preferred treatments for patients without a history of allergies. It effectively inhibits bacterial growth and alleviates symptoms such as pus formation and sore throat. The full course of treatment must be completed to avoid recurrence due to premature discontinuation.
2. **Amoxicillin Capsules**: Also belonging to the penicillin class, this drug has a broad antimicrobial spectrum and clear efficacy against bacteria associated with tonsillar abscesses. It is well absorbed orally and acts quickly. Suitable for patients without penicillin allergy, it effectively controls inflammation and reduces symptoms like pus discharge and fever. Patients should be monitored for possible allergic reactions during treatment.
3. **Cefuroxime Axetil Tablets**: A second-generation cephalosporin with strong antibacterial activity, effective against various bacteria that cause purulent tonsillitis. It is suitable for patients who are allergic to penicillin or have not responded well to it. This medication rapidly relieves inflammatory symptoms and reduces pus exudation. Dosage and duration must strictly follow medical advice to prevent the development of drug resistance.
4. **Azithromycin Dispersible Tablets**: A macrolide antibiotic suitable for patients allergic to penicillin or cephalosporins. It has stable antibacterial effects and a shorter treatment course (typically 3–5 days). It effectively inhibits bacterial protein synthesis, controlling the inflammation of purulent tonsillitis, and also shows some effectiveness against certain resistant strains. Better absorption is achieved when taken on an empty stomach.
5. **Clindamycin Capsules**: A lincosamide-class antibiotic appropriate for patients allergic to both penicillin and cephalosporins. It has potent inhibitory effects against bacteria responsible for tonsillar pus formation. It helps relieve symptoms such as suppuration and throat pain. Gastrointestinal side effects should be monitored during treatment; any discomfort should be promptly reported to a physician.
Before selecting an anti-inflammatory drug, it is essential to confirm whether there is a history of drug allergy. Medications must be used under the guidance of a doctor—self-medication without prescription is not recommended. During treatment, maintain a light diet and get adequate rest. If symptoms do not improve or worsen within three days, seek timely re-evaluation and adjustment of the treatment plan to prevent disease progression.
