Can the scab formed after cryotherapy for plantar warts be manually picked off?
Generally, the scab formed after cryotherapy for plantar warts should not be picked off manually. The detailed explanation is as follows:

The scab formed after cryotherapy serves as a natural protective barrier in the skin's self-repair process. It shields the newly forming tissue underneath from bacterial invasion and provides a stable, moist environment conducive to wound healing. Manually removing the scab disrupts this protection, exposing the new skin. This not only increases the risk of infection—manifesting as redness, swelling, and discharge—but may also lead to incomplete wound healing, raising the likelihood of wart recurrence and potentially causing scars that affect skin appearance.
In daily care, keep the scabbed area clean and dry. Avoid prolonged soaking in water; after washing feet, gently pat the area dry with a clean towel. Wear loose, soft footwear and socks to minimize friction and pressure on the scab, preventing accidental detachment. In terms of diet, avoid spicy and irritating foods, and consume more foods rich in vitamins to support skin regeneration. Allow the scab to fall off naturally. If itching occurs during the shedding process, do not scratch—gently tapping the area can help relieve discomfort.