What are the symptoms of skin keratinization?
Nov 29, 2025
Source: Cainiu Health
Dr. Liu Wenmin
Introduction
Symptoms of skin keratinization typically manifest as dry, rough skin, flaking or scaling, localized dullness in skin tone, and thickening and hardening of the skin. Abnormal keratinization can impair the skin's barrier function, accelerate moisture loss, and cause the skin surface to lose its smoothness, feeling noticeably rough to the touch. These symptoms are particularly common on limbs and cheeks, and the sensation of dryness tends to worsen during autumn and winter seasons.
Symptoms of skin keratinization typically manifest as dry and rough skin, flaking or scaling, localized dullness in skin tone, thickened and hardened skin, along with mild itching. A detailed analysis is as follows:
1. Dry and rough skin: Abnormal keratinization can impair the skin's barrier function, accelerating moisture loss. The skin surface loses its smoothness and feels noticeably rough to the touch, particularly on limbs and cheeks. This dryness tends to worsen during autumn and winter seasons.
2. Flaking and scaling: Imbalance in stratum corneum metabolism prevents dead keratinocytes from shedding normally, causing them to accumulate on the skin surface and form fine scales, often white or light yellow. These scales may shed like dandruff, commonly appearing on areas such as the lower legs and elbows. In severe cases, large patches of scales may peel off.
3. Localized dull skin tone: Accumulated keratin layers scatter light, depriving the skin of its natural luster and resulting in a dull appearance in affected areas. This creates a visible contrast with surrounding healthy skin, especially prominent on regions with high sebum production such as the forehead and chin.
4. Thickened and hardened skin: Prolonged buildup of keratin leads to thickening of the skin tissue, which feels tough or leathery upon touch. Some areas may develop slight elevations, commonly seen on palms and soles—regions subject to frequent friction. Severe thickening may compromise skin flexibility.
5. Mild itching: Abnormal keratin can irritate cutaneous nerve endings, triggering mild itchiness. Symptoms are often more pronounced in dry environments or at night. Scratching may further damage the skin and potentially lead to secondary infections.
Daily care should emphasize skin hydration. Use gentle moisturizing lotions or creams and avoid frequent application of exfoliating products. Limit bath time to 10–15 minutes and avoid excessively hot water. If symptoms persist or worsen, or if significant discomfort occurs, seek medical advice promptly for accurate diagnosis and targeted treatment.
