Why is the tetanus shot administered in the buttocks?

Dec 02, 2025 Source: Cainiu Health

Dr. Li Feng

Introduction

The tetanus vaccine is administered in the buttocks because the gluteal region has thick muscles and abundant blood vessels, which meets the requirements for intramuscular injection, promotes rapid absorption of the vaccine components, and reduces pain and adverse reactions at the injection site. If there are contraindications to vaccination or severe discomfort occurs after vaccination, prompt medical attention is recommended. The tetanus vaccine must be given via intramuscular injection.

Tetanus vaccine is administered in the buttocks because the gluteal area has thick muscles and abundant blood vessels, meeting the requirements for intramuscular injection. This promotes rapid absorption of the vaccine components while reducing pain and adverse reactions at the injection site. If there are contraindications to vaccination or severe discomfort occurs afterward, prompt medical attention is advised.

The tetanus vaccine must be delivered via intramuscular injection. The gluteus maximus in the buttocks is one of the thickest muscles in the human body, providing ample space for injection. This helps prevent accidental injury to blood vessels or nerves, reduces injection risks, and makes it particularly suitable for adults and older children.

The good blood circulation around the gluteal muscles allows the vaccine to be quickly absorbed into the bloodstream after injection, effectively stimulating the immune system to produce protective antibodies and ensuring the vaccine takes effect within the required timeframe. Compared with injections in other muscle sites, administering the vaccine in the buttocks also lowers the likelihood of local adverse reactions such as redness, swelling, or induration.

After vaccination, keep the injection site clean and dry, avoid contact with water and vigorous rubbing. Refrain from heavy physical activity within 24 hours, maintain a light diet avoiding spicy or irritating foods, drink plenty of water to support metabolism, and help the body generate a better immune response.

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