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What is Sofosbuvir and Velpatasvir Tablets used for?

Dec 02, 2025 Source: Cainiu Health
Dr. Huang Yuhong
Introduction
Sofosbuvir and velpatasvir tablets are commonly used antiviral medications, generally indicated for the treatment of adult chronic hepatitis C virus infection, including chronic hepatitis C genotype 1, genotype 2, genotype 3, and genotypes 4, 5, and 6. A detailed analysis is as follows:

Sofosbuvir and velpatasvir tablets are commonly used antiviral medications, generally indicated for the treatment of adult chronic hepatitis C virus (HCV) infection, including genotype 1, genotype 2, genotype 3, and genotypes 4/5/6 chronic hepatitis C. Specific indications are as follows:

1. Adult chronic hepatitis C virus infection: This medication is suitable for adult patients with chronic HCV infection without cirrhosis or with compensated cirrhosis. By inhibiting viral replication, it helps eliminate the virus from the body, achieving cure and improving liver function.

2. Genotype 1 chronic hepatitis C: For patients infected with hepatitis C virus genotype 1, regardless of whether they have compensated cirrhosis, this drug exerts antiviral effects, reduces ongoing liver cell damage caused by the virus, and lowers the risk of disease progression.

3. Genotype 2 chronic hepatitis C: For patients infected with hepatitis C virus genotype 2, the drug can effectively suppress the virus when used as monotherapy without the need for combination with other agents. Most patients achieve viral clearance following standardized treatment.

4. Genotype 3 chronic hepatitis C: In treating hepatitis C virus genotype 3 infection, the drug specifically targets key steps in viral replication. Even in patients with compensated cirrhosis, standardized treatment can control disease progression and improve prognosis.

5. Genotypes 4/5/6 chronic hepatitis C: For infections caused by hepatitis C virus genotypes 4, 5, and 6, the drug demonstrates broad-spectrum antiviral activity, effectively eliminating viruses of different genotypes, helping patients achieve clinical cure and reducing long-term complications.

Treatment with sofosbuvir and velpatasvir tablets must be conducted under the guidance of a qualified physician. Prior to initiating therapy, patients should undergo HCV genotyping and liver function assessment. During treatment, patients must strictly adhere to medical instructions regarding dosage and duration, and must not discontinue or adjust medication without authorization. Regular monitoring of viral load and liver function is necessary to evaluate treatment response and monitor for adverse effects.

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