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Is it necessary for adults to get the hepatitis A vaccine?

Dec 02, 2025 Source: Cainiu Health
Dr. Huang Yuhong
Introduction
If adults have never been infected with the hepatitis A virus, and their hepatitis B panel shows negative for hepatitis A antibodies, they may benefit from vaccination—especially if they face a higher risk of exposure, such as frequently eating out, working in food processing, traveling to regions where hepatitis A is prevalent, or having a weakened immune system. Receiving the hepatitis A vaccine can effectively establish an immune barrier, reduce the risk of infection, and prevent liver damage caused by the hepatitis A virus.

Generally, adults who have never been infected with hepatitis A and lack protective antibodies should consider vaccination if they are at risk of exposure. However, those who already have antibodies or a history of infection do not need vaccination. If in doubt, it is recommended to consult a healthcare provider in advance. Detailed analysis is as follows:

If an adult has never been infected with the hepatitis A virus and testing (such as a hepatitis panel) shows negative results for hepatitis A antibodies, and they face a high risk of exposure—such as frequently eating out, working in food processing, traveling to areas where hepatitis A is prevalent, or having a weakened immune system (e.g., due to chronic liver disease)—receiving the hepatitis A vaccine can effectively establish an immune barrier, reduce the risk of infection, and prevent liver damage caused by the hepatitis A virus.

If an adult has previously been infected with hepatitis A virus and developed long-lasting protective antibodies, or has already completed hepatitis A vaccination with antibodies still at effective levels, revaccination is unnecessary. These individuals maintain long-term immunity against hepatitis A virus; additional vaccination would not only be redundant but could also lead to unnecessary medical burden.

Before deciding on hepatitis A vaccination, adults may first undergo testing for hepatitis A antibodies. After vaccination, monitor for local reactions at the injection site, and seek medical attention promptly if severe redness, swelling, or fever occurs. Even after vaccination, maintaining good hygiene practices and avoiding contact with potential sources of hepatitis A contamination remain important.

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