Is 37.3°C a low-grade fever associated with AIDS?

Dec 02, 2025 Source: Cainiu Health
Dr. Ren Yi
Introduction
If there is a history of high-risk exposure to HIV, and a fever of 37.3°C persists for several days along with symptoms such as fatigue, sore throat, swollen lymph nodes, and rash, one should be alert to the possibility of acute HIV infection. During this stage, the virus actively replicates in the body, triggering an immune response that may cause low-grade fever. However, these symptoms are not unique to HIV infection, and further testing is required for confirmation.

Generally, a body temperature of 37.3°C alone is not sufficient to diagnose low-grade fever caused by HIV/AIDS. Caution is warranted if there has been high-risk exposure and other symptoms are present; in the absence of such exposure, it is usually due to common causes. If concerned, it is advisable to seek medical consultation early. Specific analysis is as follows:

If there is a history of high-risk exposure to HIV (such as unprotected sexual contact, sharing needles, etc.), and the temperature of 37.3°C persists for several days along with symptoms like fatigue, sore throat, swollen lymph nodes, or rash, acute HIV infection should be considered. During this stage, the virus actively replicates in the body, triggering an immune response that may lead to low-grade fever. However, these symptoms are not unique to HIV, and further testing is required for confirmation.

If there is no history of high-risk HIV exposure, a temperature of 37.3°C is likely unrelated to HIV. It may result from environmental heat, intense physical activity, the early stage of a common cold, or minor inflammation causing temporary fluctuations in body temperature. In such cases, the temperature typically does not continue to rise and will gradually return to normal after rest or treatment targeting common underlying causes. There is no need to overassociate this with HIV.

When a temperature of 37.3°C occurs, individuals should monitor their temperature changes and any accompanying symptoms. Those with high-risk exposure should promptly visit a qualified healthcare facility for HIV testing. Avoid self-diagnosis based solely on body temperature; rely instead on professional medical evaluation to reduce unnecessary anxiety.