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For which type of hepatitis is interferon indicated?

Dec 03, 2025 Source: Cainiu Health
Dr. Huang Yuhong
Introduction
Interferon is generally indicated for chronic hepatitis B, chronic hepatitis C, chronic hepatitis D, and some cases of hepatitis G. In chronic hepatitis B, interferon suppresses hepatitis B virus replication by modulating the immune system, and is suitable for patients with elevated serum aminotransferase levels and moderate viral load. Pegylated interferon alfa-2a or alfa-2b injection is commonly used, with a typical treatment duration of 48 weeks.

Interferon is generally indicated for chronic hepatitis B, chronic hepatitis C, chronic hepatitis D, certain cases of hepatitis G, and co-infections involving hepatitis viruses. A detailed analysis is as follows:

1. Chronic Hepatitis B: Interferon suppresses hepatitis B virus replication by modulating the immune system and is suitable for patients with elevated serum aminotransferase levels and moderate viral load. Pegylated interferon α-2a or α-2b injection is commonly used, with a typical treatment duration of 48 weeks. This regimen can improve liver function and reduce the risk of cirrhosis.

2. Chronic Hepatitis C: The combination of interferon and ribavirin was previously the standard treatment, effective against both genotype 1 and non-genotype 1 hepatitis C virus. Although the use of interferon has declined due to the widespread availability of newer oral antiviral agents, some patients still require combination therapy to slow the progression of liver fibrosis.

3. Chronic Hepatitis D: Treatment requires high-dose interferon α for at least 12 months; however, virological response rates are low, making it an alternative option only. Liver function and viral load must be closely monitored during treatment.

4. Certain Cases of Hepatitis G: Interferon therapy may be beneficial in chronic hepatitis G, particularly when co-infected with hepatitis B or C viruses. Research in this area is ongoing, and treatment efficacy should be evaluated on an individual basis.

5. Hepatitis Co-infections: In cases such as hepatitis B co-infected with hepatitis D or C, interferon may exert synergistic effects by suppressing replication of multiple viruses. However, treatment regimens must be tailored according to specific viral types and patient tolerance.

During treatment, routine monitoring of complete blood count, liver function, and thyroid function is required. Patients should promptly inform their physician if adverse effects such as fever or fatigue occur. Strict adherence to medical instructions is essential—do not adjust dosage or discontinue medication without medical guidance.

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