How long should the intervals be for the three booster doses of the hepatitis B vaccine?

Generally, the three doses of a hepatitis B vaccine booster should follow the 0-1-6 schedule: the day of the first dose is considered time point "0," the second dose is administered one month after the first, and the third dose is given six months after the first. The exact timing may be adjusted based on an individual's antibody levels.

The 0-1-6 schedule is a universally accepted standard protocol, allowing the body to gradually develop and maintain sufficient protective antibodies. The first dose primes the immune system to recognize the virus; the second strengthens immunological memory; and the third consolidates antibody levels, establishing long-term protection. If a person has been previously vaccinated but their antibody titers have declined, healthcare providers may adjust the interval—such as using a 0-1-3 schedule—based on test results to rapidly boost antibody levels. For special populations, such as those with compromised immune systems, vaccination intervals should be flexibly arranged according to medical advice.

All doses must be completed on schedule without arbitrary delays. After each injection, keep the injection site clean and avoid strenuous physical activity. One to two months after completing the full vaccination series, testing for hepatitis B surface antibody titer is recommended to confirm whether protective levels have been achieved.