Is a hepatitis B antibody level of 57 mIU/mL sufficient, or is a booster needed?

May 30, 2023 Source: Cainiu Health

Dr. Jiang Weimin

Introduction

Does an anti-HBs level of 57 mIU/mL require a booster? The term "hepatitis B antibody" here refers specifically to hepatitis B surface antibody (anti-HBs). An anti-HBs level of 57 mIU/mL generally does not require a booster. Typically, if the hepatitis B surface antibody level is greater than 10 mIU/mL, a hepatitis B vaccine booster is not necessary; however, if it is less than 10 mIU/mL, a booster dose is recommended.

"Does a hepatitis B antibody level of 57 mIU/mL require a booster?" Here, the term "hepatitis B antibody" refers to hepatitis B surface antibody. Generally, a hepatitis B surface antibody level of 57 mIU/mL does not require a booster dose. Details are as follows:

Typically, if the hepatitis B surface antibody level is greater than 10 mIU/mL, there is no need for a hepatitis B vaccine booster shot. However, if the level is less than 10 mIU/mL, a booster dose is recommended to increase antibody levels and enhance protection against infection. After receiving the hepatitis B vaccine, the body produces hepatitis B surface antibodies, which provide defense against hepatitis B virus infection.

It should be noted that hepatitis B vaccination is not a one-time, lifelong solution. Over time, antibody concentrations may decline. Therefore, it is recommended to have regular testing for hepatitis B surface antigen and antibodies (commonly known as "two sets of two" or "five-panel" testing). If the hepatitis B surface antibody level falls below 10 mIU/mL, a booster shot is necessary.

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