What percentage should adherence to antiviral medication for HIV treatment achieve?

Medication adherence in antiretroviral therapy for HIV must reach over 95%, as this is a critical requirement to suppress viral replication and control disease progression. Adherence below this level significantly compromises treatment effectiveness. If long-term adherence is inadequate or adverse drug reactions occur, prompt medical consultation is recommended to adjust the treatment regimen.

A 95% adherence rate means missing no more than 1–2 doses per month. Taking the prescribed dosage at the correct times consistently suppresses HIV replication in the body, reduces viral load, protects the immune system from further damage, lowers the risk of opportunistic infections, and prolongs patient survival.

If adherence falls below 95%, the virus is more likely to survive and mutate within the body, gradually developing drug resistance. This may render the current treatment ineffective, necessitating a switch to more complex drug regimens with potentially reduced efficacy, while also increasing the risk of transmitting the virus to others.

To maintain adherence, establish a fixed medication schedule with multiple reminders, keep medications in easily accessible locations, communicate regularly with healthcare providers about treatment experiences, and seek supportive supervision from family and friends—helping to prevent missed doses, discontinuation, or dose reduction due to forgetfulness, busy schedules, or concerns about side effects.