How long should I wait to breastfeed after taking one tablet of compound paracetamol and amantadine hydrochloride during lactation?
Dec 04, 2025
Source: Cainiu Health
Dr. Zhang Lu
Introduction
If a breastfeeding woman has normal liver and kidney function and good metabolic capacity for drugs, and has taken the regular dose of compound paracetamol and amantadine tablets, breastfeeding after a 24-hour interval is relatively safe. By this time, components such as paracetamol and amantadine have mostly been metabolized and eliminated from the body, with only minimal amounts entering breast milk, making adverse effects on the infant unlikely.
Generally, after taking one tablet of compound paracetamol and amantadine during lactation, it is recommended to wait 24 hours before resuming breastfeeding. If the drug metabolism is slow or the infant is particularly sensitive, the interval can be appropriately extended. If in doubt, it is advisable to consult a healthcare provider in advance. Detailed analysis is as follows:
If a lactating woman has normal liver and kidney function, good metabolic capacity, and takes the standard dose of compound paracetamol and amantadine tablet, breastfeeding after a 24-hour interval is relatively safe. By this time, most active ingredients such as paracetamol and amantadine have been metabolized and eliminated from the body, with only minimal amounts entering breast milk, making adverse effects on the infant unlikely.
However, if the lactating woman has impaired liver or kidney function, slow drug metabolism, or if the infant is very young (e.g., less than 3 months old) or physically sensitive (e.g., prone to rashes or diarrhea), it is recommended to extend the interval to approximately 36 hours. In such cases, ensuring sufficient drug metabolism helps further reduce residual drug levels in breast milk and prevents potential infant reactions such as drowsiness or gastrointestinal discomfort.
During medication, drink plenty of water to promote drug elimination; use a breast pump to empty the breasts temporarily to prevent engorgement. After resuming breastfeeding, closely monitor the infant’s condition and discontinue breastfeeding immediately if any abnormalities occur. For future colds, choose medications safe for use during lactation under medical guidance.
