Does the blood type of parents affect hemolytic disease?

In general, hemolytic disease, particularly hemolytic disease of the newborn, may be influenced by the parents' blood types. The specific analysis is as follows:

Hemolytic disease of the newborn often results from blood type incompatibility between mother and child. If the mother’s body lacks the blood group antigen present on the fetal red blood cells, these fetal red blood cells entering the maternal circulation can stimulate the mother to produce antibodies against that specific antigen. These antibodies then cross the placenta back into the fetal circulation, bind to the fetal red blood cells, and destroy them, causing hemolysis. Common scenarios include an O-type mother carrying an A-type or B-type baby, or an Rh-negative mother carrying an Rh-positive baby. The former commonly leads to ABO hemolytic disease, while the latter may cause Rh hemolytic disease, which is typically more severe.

Monitor the onset time, extent, and color changes of jaundice in the baby's skin; inform the doctor promptly if jaundice appears too early or progresses rapidly. Continue breastfeeding, feeding small amounts frequently to promote bowel movements and facilitate bilirubin excretion. Keep the baby’s skin clean, and dress them in soft, loose clothing to avoid skin irritation or injury from friction. Maintain warmth to prevent chilling, and gently pat the baby’s back after feeding to prevent spitting up or coughing due to choking. Regularly monitor the baby’s body temperature, weight, and mental status, and ensure a quiet, comfortable sleeping environment to support recovery.