Can you get infected by opening an antigen test kit box?

Opening an antigen test kit typically does not lead to infection; there is no need for concern if the kit is intact and handled properly. However, there may be a very low risk of infection if the kit is contaminated or handled incorrectly. The detailed analysis is as follows:

Legitimate antigen test kits undergo strict sterile procedures during manufacturing and packaging. The samples collected are intended solely for in vitro diagnosis and do not contain live viruses. As long as the kit remains sealed, is within its expiration date, and proper hand hygiene is observed—avoiding direct contact with critical areas such as the test card's reaction zone—opening the kit will not cause infection.

If the kit’s packaging is damaged, the seal is broken, or improper storage leads to contamination by pathogens, touching contaminated surfaces and then contacting mucous membranes such as the mouth or nose could pose a minimal infection risk. Additionally, performing the test with contaminated hands may increase the possibility of cross-contamination.

Before routine operation, wash hands thoroughly and preferably wear disposable gloves. Check that the kit packaging is undamaged and confirm it is within the expiration date. Perform the test promptly according to the instructions after opening, avoiding prolonged exposure of the kit to air. After testing, dispose of waste materials properly and maintain a clean working environment.