What Is Extensively Hydrolyzed Formula?
Infant formula is a widely consumed food product today. High-quality formula can better support an infant’s physical development and overall health. What is extensively hydrolyzed formula?
What Is Extensively Hydrolyzed Formula?
“Extensively hydrolyzed formula is infant formula processed using hydrolysis technology. Typically, large-molecular-weight proteins in the formula are broken down into smaller peptides or free amino acids. This process reduces the allergenicity of milk proteins—thereby helping to prevent allergic reactions in infants, as well as alleviating chronic constipation or recurrent diarrhea. Infants with a family history of allergies or those diagnosed with cow’s milk protein allergy may be prescribed extensively hydrolyzed formula.”

Hydrolyzed protein refers to protein that has undergone enzymatic or acidic hydrolysis, breaking down intact, large-molecular-weight proteins into smaller peptides or even free amino acids. Infant formulas using hydrolyzed protein as their primary protein source are termed hydrolyzed protein formulas. Based on the degree of hydrolysis, these formulas fall into three categories: partially hydrolyzed protein formula, extensively hydrolyzed protein formula, and fully hydrolyzed (amino acid-based) formula.

Extensively hydrolyzed formula is primarily indicated for children with confirmed, clinically significant cow’s milk protein allergy. It helps alleviate a range of symptoms triggered by standard formula feeding—including eczema, vomiting, constipation, and diarrhea. However, due to its bitter taste, many infants find this formula unpalatable. We hope this explanation proves helpful.