What are the differences between the attenuated and inactivated Japanese encephalitis vaccines?

There are significant differences between the live attenuated Japanese encephalitis vaccine and the inactivated Japanese encephalitis vaccine in several aspects. 1. From the perspective of production principles, the live attenuated Japanese encephalitis vaccine is a live vaccine made from processed Japanese encephalitis virus, while the inactivated Japanese encephalitis vaccine is a killed vaccine composed of bacteria and viruses that have been treated to lose their pathogenicity. 2. Regarding the number of doses required, the live attenuated Japanese encephalitis vaccine generally needs to be administered only twice due to its longer duration of action, whereas the inactivated Japanese encephalitis vaccine requires four doses to achieve optimal immunization. 3. In terms of immunity duration, the live attenuated Japanese encephalitis vaccine provides longer-lasting immunity. In contrast, because the inactivated Japanese encephalitis vaccine is made from killed viruses, its immunity is relatively short-lived, and booster vaccinations are usually required every 3 to 5 years. The choice of which vaccine to use should be made under a doctor's guidance based on individual circumstances.