What is the difference between adenocarcinoma and squamous cell carcinoma?

Jun 27, 2024 Source: Cainiu Health
Disease description:

My friend has recently been complaining of chest pain. He consulted a doctor who suspected adenocarcinoma, but after undergoing tests, he was told it is squamous cell carcinoma. Could you please explain the difference between adenocarcinoma and squamous cell carcinoma?

Doctor's answer (1)
Dr. Qi Zhirong
Adenocarcinoma and squamous cell carcinoma are two distinct types of malignant tumors with notable differences between them. 1. Different growth locations and speeds. Adenocarcinoma commonly occurs in glandular epithelium, such as in the stomach, intestines, lungs, etc., and grows relatively quickly. Squamous cell carcinoma develops in squamous cells and is frequently found in areas such as the nasopharynx, cervix, and esophagus, with a relatively slower growth rate. 2. Varied morphology and symptoms. Adenocarcinoma varies in shape and is not always well-defined; it tends to invade lymphatic and blood vessels, often leading to lymphatic metastasis. Squamous cell carcinoma mainly presents with a cauliflower-like appearance. If ulcers develop, they are typically associated with a significant odor and purulent discharge. 3. Different treatment approaches. Adenocarcinoma is primarily treated with surgery and chemotherapy, and targeted therapy has also shown good efficacy. Squamous cell carcinoma, on the other hand, is more commonly treated with radiotherapy. When cancer cells spread to lymph nodes or other parts of the body, more extensive surgery or chemotherapy may be required.