Are autoimmune diseases caused by abnormal immune function?

Jun 27, 2024 Source: Cainiu Health
Disease description:

My husband has been falling ill frequently over the past six months. He has undergone many medical checkups, and the results indicated that his immune system is weakened. I would like to ask: are autoimmune diseases caused by abnormal immune function?

Doctor's answer (1)
Dr. Yang Tiesheng
Autoimmune diseases are typically caused by abnormal immune function. Specifically: 1. Abnormal immune function: The development of autoimmune diseases is closely related to dysfunction of the immune system, such as loss of immune tolerance and excessive immune responses. 2. Loss of immune tolerance: Under normal circumstances, the immune system is tolerant to self-antigens and does not attack its own tissues. However, in certain situations, this immune tolerance may be lost, leading the immune system to mistakenly attack its own tissues. 3. Excessive immune response: In autoimmune diseases, the immune system may become overactive, producing excessive amounts of autoantibodies or activating too many immune cells, thereby causing tissue damage and inflammatory responses.