What happens if a large amount of high-concentration potassium chloride is administered intravenously?

Jun 28, 2024 Source: Cainiu Health
Disease description:

When using potassium chloride, I'm concerned that intravenous administration of large amounts of high-concentration potassium chloride may cause adverse consequences. What would happen if a large amount of high-concentration potassium chloride is given intravenously?

Doctor's answer (1)
Dr. Yang Ziqi
Intravenous administration of large amounts of high-concentration potassium chloride may result in a series of serious consequences. Specifically, it may lead to cardiovascular complications such as cardiac arrest, myocardial infarction, and angina, because high concentrations of potassium chloride can rapidly elevate serum potassium levels, thereby affecting the electrophysiological activity of myocardial cells and potentially causing cardiac arrest. Gastrointestinal symptoms such as nausea, vomiting, abdominal pain, and diarrhea, as well as systemic symptoms including hyperkalemia, arrhythmia, and dyspnea may also occur. Hyperkalemia may further cause neurological symptoms such as weakness, anxiety, numbness in the hands and feet, and confusion. When using potassium chloride injection, it is essential to strictly follow medical instructions, controlling both the concentration and infusion rate of the medication to avoid risks associated with high-concentration or rapid infusion. Healthcare providers should closely monitor patients' responses and serum potassium levels during administration, and promptly implement appropriate interventions should any abnormalities arise.