Etiology of Leukopenia

The causes of leukopenia can be mainly summarized as follows: 1. Impaired production: Decreased proliferation of hematopoietic stem cells, aplastic anemia, leukemia, myeloma, and other conditions that infiltrate the bone marrow hematopoietic tissue can all affect white blood cell production. 2. Impaired maturation: Deficiencies or metabolic disorders of folic acid and vitamin B12, myelodysplastic syndromes, and other conditions that cause impaired differentiation and maturation of hematopoietic cells. 3. Excessive destruction: Various drugs and autoimmune diseases can cause immune-mediated destruction of white blood cells, as can infections leading to excessive consumption of white blood cells. 4. Abnormal distribution: Abnormal granulocyte distribution caused by conditions such as allergy and endotoxemia. In addition, female patients are more prone to develop leukopenia due to immune system diseases.