What is Hemophilia A?
Disease description:
Our child has been diagnosed with Hemophilia A, and what the doctor said was particularly frightening. What exactly is Hemophilia A?
Doctor's answer (1)
Dr. Liu Feng
Hemophilia A, also known as antihemophilic globulin deficiency, is an inherited disorder characterized by a deficiency of coagulation factor VIII. It is an X-linked recessive genetic disease that primarily affects males. The clinical features are marked by a tendency to experience severe bleeding and difficulty in stopping bleeding after injuries, particularly in joints, skin, and mucous membranes. The pathogenesis of this condition mainly stems from defects in the FVIII gene, which result in impaired synthesis or structural abnormalities of factor VIII molecules, leading to reduced or absent functional activity. Currently, the main treatment options for hemophilia A include replacement therapy involving regular infusions of factor VIII, as well as supportive treatments such as avoiding trauma and preventing bleeding episodes.
