What are the reasons why AIDS is difficult to cure?

Jul 07, 2024 Source: Cainiu Health
Disease description:

I read in reports that many AIDS patients need to take medication for life to control the virus, and AIDS cannot currently be cured. May I ask why it is so difficult to cure AIDS?

Doctor's answer (1)
Dr. Yang Ziqi
The reasons why AIDS is difficult to cure are as follows: 1. Viral characteristics: The human immunodeficiency virus (HIV) is a highly mutable RNA virus. It is covered with glycoproteins on its surface, making it difficult for the immune system to detect and effectively attack. Additionally, the virus can integrate into the host cell's genome to replicate, forming viral reservoirs that are difficult to eliminate. 2. Immune system damage: HIV primarily attacks CD4 T cells of the immune system, leading to gradual immune system failure. This weakens the body's ability to fight infections and diseases and increases the difficulty of treatment. 3. Limitations of medications: Currently, there is no drug capable of completely eliminating HIV. Existing medications can only suppress viral replication but cannot eradicate the virus at its source. Once medication is stopped, the virus can begin replicating again, causing disease recurrence. 4. Viral drug resistance and transmissibility: HIV easily develops drug resistance, reducing the effectiveness of treatment over time. Additionally, the virus is highly contagious, increasing the challenges of prevention and control. If you have any concerns, please consult a relevant healthcare professional.