What is Type II Renal Tubular Acidosis?
Disease description:
I often feel that my body is not in good condition. Many times, I feel discomfort in my renal tubules, have problems with my urinary tract, and also have a sour taste in my mouth. The doctor diagnosed me with type II renal tubular acidosis. I am very curious, what is type II renal tubular acidosis?
Doctor's answer (1)
Dr. Yang Ziqi
Type II renal tubular acidosis is a kidney disorder caused by dysfunction of the proximal tubules, particularly a reduced capacity of the proximal tubules to reabsorb sodium bicarbonate, leading to hyperchloremic acidosis. Its typical symptoms include hyperchloremic metabolic acidosis, hypokalemia, muscle weakness, polyuria, polydipsia, and thirst. The urine pH can drop below 5.5, and patients may also experience fatigue, anorexia, nausea, and vomiting. Additionally, because the proximal tubules' ability to reabsorb substances such as phosphate, glucose, uric acid, and amino acids is also impaired, increased excretion of these substances may occur, clinically manifesting as Fanconi syndrome. The etiology of Type II renal tubular acidosis is diverse, including genetic disorders, primary diseases, effects of drugs or toxins, and other conditions. Treatment mainly involves addressing the underlying cause and providing symptomatic and supportive management to correct acidosis and electrolyte imbalances.
