What tissue regeneration occurs during the healing process of gastric ulcers?
Disease description:
Postprandial epigastric pain is always present. Gastroscopy revealed a gastric ulcer. The patient is taking medication regularly as prescribed. I would like to understand what tissue regeneration occurs during the healing process of a gastric ulcer.
Doctor's answer (1)
Dr. Shen Yonghua
During the healing process of gastric ulcers, tissue regeneration mainly involves:
1. Regeneration of submucosal tissue: In the later stages of gastric ulcer healing, the submucosal tissue also undergoes regeneration, further strengthening the defensive function of the gastric mucosa and preventing subsequent erosion of the gastric wall by gastric acid and other digestive fluids.
2. Epithelial cell regeneration: Damaged gastric mucosal epithelial cells repair the ulcerated area through proliferation and migration of basal layer cells, forming a new epithelial layer to restore the integrity of the gastric mucosa.
3. Gastric mucosal regeneration: Gastric ulcers occur when the gastric mucosa is damaged, leading to self-digestion of the submucosal tissue by gastric acid and other digestive fluids, resulting in an ulcerative lesion. During treatment and repair, the gastric mucosa gradually regenerates and restores its original protective barrier function.
4. Gastric glands: Damaged gastric glands reconstruct glandular structures through activation and differentiation of stem cells, restoring normal secretion function of gastric juice.
This regenerative process of the tissues not only relies on the patient's own repair capacity but also requires assistance through pharmacological treatments and other therapeutic measures.
