The Role of Trimetazidine Hydrochloride
I recently had a persistent feeling of chest pain and tightness. After visiting the hospital, my doctor prescribed me Trimetazidine Hydrochloride. What is the function of Trimetazidine Hydrochloride?
Doctor's answer (1)
As a commonly used cardiovascular medication, Trimetazidine Hydrochloride mainly exerts its effects in the following aspects:
1. Alleviating angina pectoris: By modulating cellular energy metabolism, especially under hypoxic conditions, it promotes the shift from fatty acid oxidation to glucose oxidation, thereby optimizing the energy utilization efficiency of the myocardium. This process reduces the heart's oxygen demand and improves energy supply to the myocardium under ischemic conditions, thus relieving symptoms of angina pectoris.
2. Nourishing the myocardium: Trimetazidine Hydrochloride promotes glucose utilization by activating pyruvate dehydrogenase or inhibiting carnitine palmitoyltransferase-1, thereby enhancing energy metabolism within myocardial cells and effectively nourishing the myocardium.
3. Improving metabolism: This drug can reduce vascular resistance, enhance blood circulation and metabolism, alleviate pressure and burden on the heart, and help improve the ischemic and hypoxic state of the myocardium.
4. Anti-arrhythmic and neuronal protection: This may be related to its ability to stabilize cellular membrane potential and reduce calcium ion influx, which helps prevent arrhythmias and neuronal damage caused by ischemia.
